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As can be seen in Figure 1.9 thenet effect of dividing the threshold or noAEL dose bysome total safety/uncertainty factor is that it is equivalentto selecting a substantially lower dose from the no-effectregion of the dose–response curve. These death regulators (BID, BAX, BAK, BIM, and BAD)and how they function not only control mitochondrial apoptosis, but also these proteins can?sense‘ cell damage as they transit through the cytoplasm of a cell (Gross 1999).

The ureteral stents are secured with a silk suture to the skin, and anexternal urine collection device is placed. The ureters are connected to the proximal portion of this tubularized limb in asimilar fashion used for an ileal conduit. Several techniques (e.g., tracheal gasinsuf?ation) (Davies and Woodgate 2002; Milleret al

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